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Serum α‐L‐Fucosidase: A New Marker for the Diagnosis of Primary Hepatic Carcinoma?
Author(s) -
Deugnier Yves,
David Véronique,
Brissot Pierre,
Mabo Philippe,
Delamaire Damien,
Messner Michel,
Bourel Michel,
Legall JeanYves
Publication year - 1984
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840040516
Subject(s) - primary (astronomy) , tumor marker , medicine , pathology , carcinoma , gastroenterology , cancer , physics , astronomy
α‐L‐fucosidase, a lysosomal enzyme which catabolizes fucoproteins, was studied in sera from 30 controls, 32 patients with primary hepatic carcinomas, 24 patients with secondary metastatic liver carcinomas and 36 patients with cirrhosis. Serum α‐L‐fucosidase was increased in primary hepatic carcinomas (145.5 ± 12 nkat per liter) with a high statistical significance versus controls (51.4 ± 4.5 – p & 10 −7 ), secondary metastatic liver carcinomas (58.9 ± 6.4 – p < 10 −5 ) and cirrhotics (71.3 ± 6 – p < 10 −5 ). A level exceeding 110 was a useful marker for the diagnosis of primary hepatic carcinoma with 75% sensitivity and 90% specificity.