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16,16‐Dimethyl‐PGE 2 Protection Against α — Napthy lisothiocy anate – Induced Experimental Cholangitis in the Rat
Author(s) -
Ruwart Mary J.,
Rush Bob D.,
Friedle Nanette M.,
Stachura Jerzy,
Tarnawski Andrzej
Publication year - 1984
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840040415
Subject(s) - alkaline phosphatase , necrosis , saline , medicine , bilirubin , endocrinology , parenchyma , hepatology , chemistry , pathology , enzyme , biochemistry
Male rats were treated with subcutaneous vehicle or 16, 16‐dimethyl‐PGE 2 (dmPGE 2 , 100 μg per kg), 24,18 and 0.5 hr prior to and 6, 24 and 30 hr after challenge with oral α1‐napthylisothio‐cyanate (ANIT, 30 mg per kg). Forty‐eight hours after challenge, rats were sacrificed by decapitation; serum and liver samples were taken for biochemical and histological analysis, respectively. Rats treated with vehicle (2% ethanol in saline) and ANIT exhibited elevations in alkaline phosphatase, SGPT and bilirubin as well as cholangitis and mild parenchymal necrosis. Rats treated with dmPGE2 and ANIT had normal serum biochemical findings, no necrosis and only mild proliferation of bile duct epithelium. Thus, dmPGE 2 may be able to protect the rat liver against the deleterious effects of orally administered ANIT.