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Nuclear Particles of Non‐A, Non‐B Type in Healthy Volunteers and Patients with Hepatitis B
Author(s) -
Spichtin Hanspeter,
Gudat Fred,
Berthold Hans,
Krey Gunthild,
Schmid Martin,
Pirovino Mauro,
Altorfer Josef,
Stalder Georg,
Eder Gerald,
Bianchi Leonardo
Publication year - 1984
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840040326
Subject(s) - hepatitis , hepatitis b , ultrastructure , medicine , pathology , histology , incidence (geometry) , virology , physics , optics
In an electron microscopic study, nuclear aggregates of virus‐like spherical and tubular particles measuring 20 to 29 nm in diameter were found in 5 of 7 clinically healthy volunteers with normal liver histology, 6 of 10 patients with hepatitis B and 17 of 18 patients with hepatitis non‐A, non‐B. The incidence of hepatocytes containing nuclear particles was approximately 0.5 to 2% in all three groups. We conclude that these nuclear particles are not specific ultrastructural markers of hepatitis non‐A, non‐B in man as originally claimed for experimental hepatitis non‐A, non‐B in chimpanzees.