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Chronic Bile Duct Ligation in the Dog: Hemodynamic Characterization of a Portal Hypertensive Model
Author(s) -
Bosch Jaime,
Enriquez Rosa,
Groszmann Roberto J.,
Storer Edward H.
Publication year - 2007
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840030618
Subject(s) - medicine , portal hypertension , splanchnic , portal venous pressure , hemodynamics , hyperdynamic circulation , vascular resistance , ligature , splanchnic circulation , cirrhosis , shunting , cardiac index , cardiology , common bile duct , bile duct , gastroenterology , cardiac output
Splanchnic and systemic hemodynamics were measured in six normal dogs and in 18 dogs that had the bile ducts ligated for a period of 8 weeks. In the bile duct‐ligated dogs, there was a decrease in arterial pressure (110 ± 4 mm Hg vs. normal 136 ± 6 mm Hg; p < 0.005) and peripheral vascular resistance (4.60 ± 0.38 vs. 6.28 ± 0.38 dynes‐sec‐cm−5; p < 0.02), and an increase in cardiac index (129 ± 7 vs. 98 ± 9 ml per min per kg; p < 0.05). The splanchnic hemodynamic characteristics in the bile duct‐ligated dogs included an increase in portal venous pressure (13.3 ± 0.6 mm Hg vs. 6.7 ± 0.5 mm Hg; p < 001) and wedged hepatic venous pressure (14 ± 1.2 mm Hg), the development of extensive portal‐systemic shunting (49 ± 10 vs. 0.03 ± 0.017c; p < 0.01), and a decrease in portal venous flow (194 ± 21 ml per min vs. 427 ± 21 ml per min; p < 0.001). This study demonstrated that chronic bile duct‐ligated dogs develop sinusoidal portal hypertension with extensive portal‐systemic shunting and a hyperdynamic systemic circulation. These findings closely resembled hemodynamic abnormalities observed in human cirrhosis and suggest that this model is useful in physiopathological and pharmacological studies of portal hypertension.