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Transplantation of Woodchuck Hepatocellular Carcinoma in Nude Mice
Author(s) -
Kobayashi Kenichi,
Fukuoka Kenichi,
Matsushita Fumiaki,
Morimoto Hideo,
Hinoue Yoshinobu,
Honjo Hideo,
Tanaka Nobuyoshi,
Sugimoto Tatsuho,
Kato Yasuhiro,
Hattori Nobu,
Ueda Shigeharu,
Kato Shiro
Publication year - 2007
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840030506
Subject(s) - hepatocellular carcinoma , woodchuck hepatitis virus , transplantation , nude mouse , in vivo , medicine , carcinoma , carcinogenesis , pathology , cancer research , hepatitis b virus , biology , immunology , virus , cancer , hepadnaviridae , microbiology and biotechnology
Woodchuck hepatocellular carcinoma has been successfully transplanted into nude (athymic) mice. The morphology of heterotransplanted tumor is similar to that of naturally occurring hepatocellular carcinoma before transplantation. The growth rate of transplanted tumor was very slow compared with those of other transplanted tumors. During the first month, only two tumors appeared. However, definitive tumor growth was noted in 6 of 20 nude mice about 3 months later. Seventeen of 20 nude mice exhibited sustained tumor growth after 6 months. The woodchuck hepatocellular carcinoma in nude mice provides an in vivo model for the study of oncogenesis of human hepatocellular carcinoma related to hepatitis B virus.