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Cytoplasmic Tubular Structures in Liver of HBsAg Carrier Chimpanzees Infected with Delta Agent and Comparison with Cytoplasmic Structures in Non‐A, Non‐B Hepatitis
Author(s) -
Kamimura Tomoteru,
Ponzetto Antonio,
Bonino Ferruccio,
Feinstone Stephen M.,
Gerin John L.,
Purcell Robert H.
Publication year - 2007
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840030502
Subject(s) - cytoplasm , hbsag , virology , hepatitis , hepatitis b , biology , human liver , hepatitis b antigens , antigen , immunology , hepatitis b virus , microbiology and biotechnology , virus , biochemistry , enzyme
Electron microscopic observations were carried out on five HBsAg carrier chimpanzees infected with delta (δ) agent and two chimpanzees infected with human non‐A, non‐B hepatitis. The cytoplasmic tubular structures, which have been recognized in the liver of chimpanzees infected with human non‐A, non‐B hepatitis, were found also in the liver of HBsAg carrier chimpanzees infected with 5 agent. The quantity of the cytoplasmic structures in serial studies was associated with SGPT elevation rather than with expression of ± antigen in sera and liver tissues. This indicates that the cytoplasmic structures reflect a pathologic change of the hepatocytes in chimpanzees infected with ± agent or human non‐A, non‐B hepatitis. These and other similarities between the two agents suggest a similar nature.