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Seroimmunologic Classification of Chronic Hepatitis in 57 Children
Author(s) -
Odièvre Michel,
Maggiore Giuseppe,
Homberg JeanClaude,
Saadoun Fabrice,
Courouce AnneMarié,
Yvart Jeannine,
Hadchouel Michelle,
Alagille Daniel
Publication year - 2007
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840030320
Subject(s) - medicine , hbsag , endoplasmic reticulum , antibody , chronic hepatitis , hepatitis , immunology , hepatitis a virus , gastroenterology , virology , virus , hepatitis b virus , biology , biochemistry
A seroimmunologic evaluation of 57 children with chronic hepatitis is presented. Twenty‐one patients had chronic persistent hepatitis and 36 had chronic active hepatitis. Serum samples obtained before treatment were tested for HBsAg, anti‐HBs, anti‐HBc, smooth muscle antibody, and antibody to endoplasmic reticulum. A persistently positive HBsAg was observed in the serum of 18 of the 21 patients with chronic persistent hepatitis. The chronic active hepatitis group was divided into three subgroups according to the presence of hepatitis B‐virus markers (7 patients), smooth muscle antibody (10 patients), and endoplasmic reticulum antibody (9 patients). Determination of these markers could be useful for classifying children with chronic hepatitis.