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Endocytic Capacities of Kupffer Cells Isolated from the Human Adult Liver
Author(s) -
Kirn André,
Bingen Annick,
Steffan AnneMarie,
Wild MarieThérèse,
Keller Francoise,
Cinqualbre Jacques
Publication year - 2007
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840020205
Subject(s) - phagocytosis , kupffer cell , endocytic cycle , opsonin , in vitro , biology , virus , human liver , liver cytology , virology , immunology , microbiology and biotechnology , pathology , medicine , endocytosis , cell , liver metabolism , endocrinology , biochemistry
Kupffer cells isolated from human adult livers and maintained in culture display the main structural features of macrophages. They are able to phagocytose latex particles and opsonized sheep erythrocytes in vitro. Vaccinia virus as well as Frog Virus 3 are taken up and uncoated in cultured Kupffer cells. Such a model may be used advantageously for studying different problems in liver physiopathology.