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The Effect of Portal Diversion on the Early Stages of Liver Carcinogenesis in the Rat
Author(s) -
Rotstein Lorne E.,
Makowka Leonard,
Lee George,
Farber Emmanuel
Publication year - 2007
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840020111
Subject(s) - carcinogen , hepatectomy , carcinogenesis , medicine , pathology , biology , cancer , resection , surgery , biochemistry
The effect of portal diversion by ameroid constriction was studied in the carcinogenic process in the rat after initiation of foci by diethylnitrosamine and after the establishment of putative preneoplastic nodules. Portal diversion or portal diversion plus partial hepatectomy did not act to promote or select for the development of nodules. Furthermore, portal diversion did not alter the natural history of established nodules. These results suggest that vascular factors are not important at these early stages of the carcinogenic process in the rat liver.