z-logo
Premium
Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
Author(s) -
Knodell Robert G.,
Ishak Kamal G.,
Black William C.,
Chen Thomas S.,
Craig Robert,
Kaplowitz Neil,
Kiernan Thomas W.,
Wollman Jerome
Publication year - 1981
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840010511
Subject(s) - asymptomatic , histology , medicine , liver biopsy , biopsy , pathology , fibrosis , hepatitis , pathological , gastroenterology , necrosis
A Histology Activity Index has been developed which generates a numerical score for liver biopsy specimens obtained from patients with asymptomatic chronic active hepatitis. Biopsies are graded in four categories: periportal necrosis, intralobular necrosis, portal inflammation, and fibrosis. Under code, three pathologists and three hepatologists evaluated 14 liver biopsy specimens obtained from five patients with asymptomatic chronic active hepatitis. Good correlation was seen between severity of liver biopsy lesions as judged by conventional histological descriptions and Histology Activity Index scores. Significant differences in Histology Activity Index score occurred in only 2 of 28 duplicate scorings of biopsy specimens by two observers. This system provides definitive endpoints for statistical analysis of serial changes in liver histology and offers an alternative to the use of conventional pathological descriptions in following the natural history and treatment responses of asymptomatic chronic active hepatitis.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here