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Effect of chronic alcohol intake on hepatic fibrosis and granulomas in marine schistosomiasis mansoni
Author(s) -
Orrego Hector,
Israel Yedy,
Crossley Ian R.,
Mahmoud Adel A. F.,
Peters Pierre A.,
Varghese George,
Wanless Ian R.
Publication year - 1981
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840010508
Subject(s) - schistosomiasis , schistosoma mansoni , granuloma , fibrosis , alcohol , hepatic fibrosis , hydroxyproline , alcohol consumption , pathology , immunology , schistosoma , physiology , biology , medicine , helminths , biochemistry
In consideration of the vast prevalence of schistosomiasis and heavy alcohol consumption in many parts of the world, the possibility of an interaction between these two conditions inducing liver disease was studied in mice infected with Schistosoma mansoni . Alcohol consumption significantly reduced by 25% the mean granuloma diameter and by about 60% the extent of fibrous tissue deposition determined chemically as hydroxyproline. DNA, as an expression of the inflammatory and cellular components of the granulomatous reaction in the infected animals, was also significantly reduced by alcohol consumption. These results indicate the need for epidemiological studies in the clinical manifestations and course of schistosomiasis in human alcoholics.