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Basic science reviews: Immunomodulation therapy for squamous cell carcinoma of the head and neck
Author(s) -
Lee Norris K.,
Cortesina Giorgio,
De Stefani Antonella,
Sacchi Manuela,
Rosso Stefano,
Galeazzi Emanuela
Publication year - 1993
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.2880150318
Subject(s) - head and neck squamous cell carcinoma , head and neck , medicine , basal cell , head and neck cancer , oncology , radiation therapy , surgery
The role of the immune system in the pathogenesis and treatment of cancer is currently a popular area of research. An underlying fundamental concept of cancer immunology is the supposition that tumor cells express antigens differently than normal cells, both qualitatively and quantitatively. Understanding tumor–host interactions may suggest opportunities to modify these relationships to obtain antitumor effects. There is growing evidence that the immune system plays an important role in the pathogenesis of squamous cell carcinoma of the head and neck (SCCHN). 1‐4 Based on this evidence, trials studying the therapeutic efficacy of biologic response modifiers (BRMs) have been undertaken. These trials have had variable success, but continued efforts incorporating newer cytokines are underway.