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Epithelial membrane antigen and S‐100 protein‐labeled cells in primary and metastatic laryngeal carcinomas
Author(s) -
Nakashima Tadashi,
Yano Gen,
Hayashi Itsuroh,
Katsuta Yasaburoh
Publication year - 1992
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.2880140604
Subject(s) - antigen , primary (astronomy) , pathology , cancer research , medicine , chemistry , immunology , physics , astronomy
Immunohistochemical studies were done on the expression of S‐100 protein‐labeled cells in human laryngeal carcinoma of epithelial membrane antigen (EMA) and on the population density. EMA was detected in 65 of 76 (86%) squamous cell carcinomas and was usually more extensively positive in well and moderately differentiated carcinomas. Thus, EMA can serve as a marker of malignancy in laryngeal carcinomas. The population density of S‐100 protein‐labeled cells was high in well‐differentiated tissues. In the metastatic tumors, the number of S‐100 protein‐labeled cells decreased as compared to findings in the primary tumors. As a statistically significant difference in survival curve was noted between groups with low and intermediate density of S‐100 protein‐labeled cells, the infiltration of S‐100 protein‐labeled cells seems to be associated with a better prognosis. © 1992 John Wiley & Sons, Inc.