Variables predicting oral mucosal lesions in allogenic bone marrow recipients | Zendy

Mattsson Torsten | Zendy; Heimdahl Anders | Zendy; Dahllof Goran | Zendy; Nilsson Bo | Zendy; Lonnqvist Berit | Zendy; Ringdén Olle | Zendy

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Variables predicting oral mucosal lesions in allogenic bone marrow recipients

Author(s) -

Mattsson Torsten,

Heimdahl Anders,

Dahllof Goran,

Nilsson Bo,

Lonnqvist Berit,

Ringdén Olle

Publication year - 1991

Publication title -

head and neck

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 127

eISSN - 1097-0347

pISSN - 1043-3074

DOI - 10.1002/hed.2880130311

Subject(s) - medicine , white blood cell , bone marrow , univariate analysis , bone marrow transplant , bone marrow transplantation , total body irradiation , transplantation , gastroenterology , oral cavity , pathology , multivariate analysis , chemotherapy , dentistry , cyclophosphamide

One hundred and forty‐eight (72%) of 205 allogenic bone marrow transplant recipients developed mucosal lesions in the oral cavity during the aplastic period after transplantation. Lesions were most frequent 8 to 9 days after transplantation. Factors that correlated with the development of mucosal lesions after univariate and multivariate analysis were a marrow cell dose of < 3 × 10 8 cells/kg body weight, ( p < 0.0001), prolonged aplastic period (white blood cell count < 0.2 × 10 9 ) cell/l during more than 14 days ( p < 0.005), herpes simplex virus‐1 seropositivity of the recipient ( p < 0.01), and conditioning with total body irradiation ( p < 0.02).

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