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Radioresistant tumor cell lines derived from head and neck radiation failures
Author(s) -
Weichselbaum Ralph R.,
Beckett Michael A.,
Vijayakumar Srinivasan,
AhmedSwan Susan,
Dritschilo Anatoly,
Schwartz Jeffrey L,
Moran William J.,
Goldman Michael E.,
Tybor Allen G.,
Vokes Everett E.,
Panje William R.
Publication year - 1989
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.2880110410
Subject(s) - radioresistance , radiation therapy , head and neck cancer , cell culture , cancer research , in vitro , head and neck , head and neck squamous cell carcinoma , sarcoma , ionizing radiation , medicine , radiosensitivity , cancer , cell , pathology , oncology , biology , irradiation , surgery , genetics , physics , nuclear physics
We studied the in vitro radiobiological parameters of 16 human head and neck squamous cell carcinoma tumor cell lines cultured from patients who suffered local failure after a curative course of radiotherapy. The radiobiological parameters determined included D 0 , n , and D̄ . When compared with in vitro radiobiological parameters of tumor cells cultured from head and neck cancer patients prior to radiotherapy, human sarcoma cell lines, and normal human diploid fibroblasts studied in our laboratory (as well as other human tumor cell lines reported in the literature), tumor cells derived from radiotherapy failures on average are resistant to the cytotoxic effects of ionizing radiation.