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Carcinoma of the skin of the head and neck with perineural invasion
Author(s) -
Mendenhall William M.,
Parsons James T.,
Mendenhall Nancy Price,
Brant Timothy A.,
Stringer Scott P.,
Cassisi Nicholas J.,
Million Rodney R.
Publication year - 1989
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.2880110404
Subject(s) - medicine , radiation therapy , perineural invasion , head and neck , surgery , incidence (geometry) , adjuvant radiotherapy , carcinoma , head and neck cancer , distant metastasis , metastasis , cancer , physics , optics
This is an analysis of 25 patients with carcinoma of the skin of the head and neck with clinical evidence of perineural invasion, who were managed with curative intent by radiotherapy alone (16) or surgery and radiotherapy (9). All patients had a minimum of 5 years of follow‐up. Local control following treatment was observed in 20% of patients treated with radiotherapy alone and 38% of those treated with surgery and radiotherapy. Local control was diminished for recurrent lesions and for tumors that also invaded bone and/or cartilage. The 5‐year absolute survival rates were 31% for patients treated with radiotherapy alone and 33% for those in the combined‐treatment group. The incidence of significant complications was similar: 25% with radiotherapy alone and 33% with surgery and adjuvant radiotherapy.