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Hyperparathyroidism subsequent to radioactive iodine therapy for Graves' disease
Author(s) -
Law Richard H.,
Quan Daniel L.,
Stefan Andrew J.,
Peterson Edward L.,
Singer Michael C.
Publication year - 2021
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26786
Subject(s) - medicine , primary hyperparathyroidism , graves' disease , hyperparathyroidism , retrospective cohort study , radioactive iodine , disease , cohort , surgery , thyroid
Background The development of primary hyperparathyroidism (PHPT) after radioactive iodine (RAI) treatment for thyroid disease is poorly characterized. The current study is the largest reported cohort and assesses the disease characteristics of patients treated for PHPT with a history of RAI exposure. Methods A retrospective analysis comparing patients, with and without a history of RAI treatment, who underwent surgery for PHPT. Results Twenty‐eight of the 469 patients had a history of RAI treatment, all for Graves' disease. Patients with a history of RAI exposure had similar disease characteristics compared to control; however, patients with a history of RAI treatment had a higher rate of recurrence (7.4% vs 1.2%, p = 0.012). Conclusion PHPT in patients with a history of RAI treatment can be approached in the same manner as RAI naive PHPT patients; however, the risk of recurrence of PHPT in RAI exposed patients may be higher.