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The preoperative C‐reactive protein–lymphocyte ratio and the prognosis of oral cavity squamous cell carcinoma
Author(s) -
Ko ChienAn,
Fang KuHao,
Hsu ChengMing,
Lee YiChan,
Chang GengHe,
Huang Ethan I.,
Tsai MingShao,
Tsai YaoTe
Publication year - 2021
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26738
Subject(s) - nomogram , medicine , hazard ratio , biomarker , oncology , receiver operating characteristic , proportional hazards model , basal cell , concordance , gastroenterology , c reactive protein , stage (stratigraphy) , inflammation , confidence interval , paleontology , biochemistry , chemistry , biology
Background We aimed to investigate the preoperative C‐reactive protein (CRP)–lymphocyte ratio (CLR) as a prognostic biomarker in oral cavity squamous cell carcinoma (OSCC). Methods Three hundred and sixteen patients with OSCC treated with curative surgery were retrospectively assessed and the receiver operating characteristic curve was used to evaluate the discriminative ability of inflammatory markers. The prognostic value of CLR was investigated with Cox proportional hazards analysis. Results The CLR cutoff of 3.88 ( p < 0.001) demonstrated optimal prognostic performance compared with other inflammatory combinations. A higher preoperative CLR (≥3.88) was significantly associated with clinicopathological aggressiveness and predicted unfavorable overall survival and disease‐free survival (hazard ratios = 3.498 and 1.994, respectively; both p < 0.001). The CLR‐based nomogram provided accurate survival prediction (concordance index: 0.803). Conclusions Preoperative CLR is a feasible prognostic biomarker in patients with OSCC, and the CLR‐based nomogram might serve as prognostic tool in era of personalized medicine.