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Melanoma of the lacrimal drainage system: A systematic review
Author(s) -
Vinciguerra Alessandro,
Rampi Andrea,
Giordano Resti Antonio,
Barbieri Diego,
Bussi Mario,
Trimarchi Matteo
Publication year - 2021
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26705
Subject(s) - medicine , cochrane library , radiation therapy , surgery , systematic review , medical literature , scopus , melanoma , medline , general surgery , dermatology , pathology , randomized controlled trial , cancer research , political science , law
Melanoma of the lacrimal drainage system (LDSM) is a rare and subtle condition that is frequently misdiagnosed. In the present work, we conducted a systematic review investigating the clinical features, management, and prognosis of LDSM. A structured search, according to PRISMA criteria, was performed in April 2020 and updated in February 2021 on Pubmed, EMBASE, Cochrane, and SCOPUS. The articles found underwent a double‐reviewer selection and the main data were extracted. After complete screening, 30 articles reporting 38 cases were included. The time from the first symptom to medical contact ranged from 1 month to 4 years. Surgery was the treatment proposed to all patients, with a variable extension of resection. LDSM is a rare disease that is burdened by poor prognosis. Early diagnosis is crucial, even if difficult to achieve. Surgery and radiotherapy are standardized treatments, while targeted therapy and immunotherapy are attractive prospects.