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Intensity‐modulated radiation therapy for nasal cavity and paranasal sinus tumors: Experience from a single institute
Author(s) -
Laskar Sarbani Ghosh,
Pai Prathamesh,
Sinha Shwetabh,
Budrukkar Ashwini,
Nair Deepa,
Swain Monali,
Mummudi Naveen,
Gupta Tejpal,
Murthy Vedang,
Agarwal Jai Prakash,
Tiwari Neelesh,
Thiagrajan Shiva,
Chaukar Devendra,
Chaturvedi Pankaj,
Pantvaidya Gouri,
Deshmukh Anuja,
Nair Sudhir,
Prabhash Kumar,
Joshi Amit,
Noronha Vanita,
Patil Vijay,
Me Nandini,
Patil Asawari,
Bal Munita,
Mittal Neha,
Rane Swapnil
Publication year - 2021
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26669
Subject(s) - medicine , nasal cavity , adenoid cystic carcinoma , univariate analysis , histology , radiation therapy , sinus (botany) , paranasal sinuses , radiology , retrospective cohort study , carcinoma , surgery , multivariate analysis , botany , biology , genus
Background To assess the efficacy of intensity‐modulated radiation therapy (IMRT) for tumors of the nasal cavity and paranasal sinus (PNS) region. Materials and Methods Two hundred fourteen patients with tumors of the nasal cavity and PNS region treated with curative intent IMRT between 2007 and 2019 were included in this retrospective analysis. Results Fifty‐one (24.1%) received definitive RT/CTRT and 163 (75.9%) received adjuvant RT. Most common histology was squamous cell carcinoma (26.1%) followed by adenoid cystic carcinoma (21.5%). The median follow‐up was 43.5 months. The 5‐year local control (LC), event‐free survival (EFS), and overall survival (OS) for the entire cohort was 66.9%, 59%, and 73.9%, respectively. On univariate analysis treatment with nonsurgical modality, T classification and undifferentiated/poorly differentiated histology were associated with inferior 5‐year LC, EFS, and OS. Four patients had late Grade 3/Grade 4 ocular toxicity. Conclusions IMRT should be the standard of care for tumors of PNS region across all histologies and treatment setting.