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Risk of second primary malignancy after minor salivary gland cancer: A Surveillance, Epidemiology, and End Results database analysis
Author(s) -
Yang Jingyi,
Wei Ruoyan,
Song Xiaole,
Sun Xicai,
Wang Huan,
Liu Quan,
Hu Li,
Yu Hongmeng,
Wang Dehui
Publication year - 2021
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26641
Subject(s) - medicine , epidemiology , radiation therapy , malignancy , salivary gland cancer , surveillance, epidemiology, and end results , cancer , oncology , population , stage (stratigraphy) , head and neck cancer , head and neck , surgery , cancer registry , biology , paleontology , environmental health
Background Minor salivary gland cancer (MiSGC) is a group of tumors with varied disease course in the head and neck. We evaluated the risk of a second primary malignancy (SPM) in MiSGC patients and identified possible prognostic factors for survival using a large population database. Methods We used the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) data to evaluate the risk and prognosis of SPM in patients diagnosed with MiSGC. Results The risk of SPM increased in MiSGC patients compared with the endemic rate. The risk of SPM was slightly greater in female patients and who underwent radiotherapy. Age at primary diagnosis, sex, race, year of diagnosis, SEER stage, radiotherapy, SPM, histology, and tumor site were significant survival prognostic indicators of MiSGC patients. Conclusion Radiotherapy and female sex were risk factors for SPM after MiSGC. Long‐term surveillance for SPM was important in MiSGC patients.