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Muscle invasion in oropharyngeal carcinoma undergoing transoral robotic surgery
Author(s) -
McKenzie Robert M.,
Parhar Harman S.,
Ng Tony L.,
Prisman Eitan
Publication year - 2021
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26582
Subject(s) - lymphovascular invasion , medicine , perineural invasion , pathological , stage (stratigraphy) , surgical margin , t stage , carcinoma , transoral robotic surgery , retrospective cohort study , basal cell , resection margin , oncology , pathology , surgery , overall survival , metastasis , cancer , resection , biology , paleontology
Backgrounds Pathologic features of oropharyngeal squamous cell carcinoma (OPSCC) treated with trans‐oral robotic surgery predict prognosis and adjuvant therapy. We hypothesized that pathologic muscle invasion (pMI) is associated with poor pathological markers. Methods Retrospective review of surgically treated OPSCC to identify pMI and its association with poor pathologic markers. Results pMI was present in 12/37 patients, and compared to non‐pMI, was associated with higher rates of lymphovascular invasion (75% vs. 36%, p = 0.03), perineural invasion (16.7% vs. 0%, p = 0.04), extranodal extension (66.7% vs. 20%, p < 0.01), and tumor stage (8.3% vs. 48% pT1, 75% vs. 52% pT2 and 16.7% vs. 0% pT3). pMI was associated with having a positive margin on main specimen (41.7% vs. 12%, p = 0.04) but not after considering additional margins. Conclusions Muscle invasion was associated with higher pathologic tumor staging, poor pathologic factors, and higher rates of positive margin on main specimen.