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Parotid gland stem cells: Mini yet mighty
Author(s) -
Sari Sezin Yuce,
Yilmaz Melek Tugce,
Elmali Aysenur,
Yedekci Fazli Yagiz,
Yuce Deniz,
Ozyigit Gokhan,
Cengiz Mustafa,
Yazici Gozde
Publication year - 2021
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26556
Subject(s) - stem cell , salivary gland , parotid gland , medicine , nuclear medicine , pathology , biology , microbiology and biotechnology
Background Our aim was to evaluate the correlation between the radiation doses to parotid gland (PG) stem cells and xerostomia. Methods Patients diagnosed with head and neck cancer (HNC) were retrospectively evaluated, and xerostomia inventory (XI) was applied to these patients. PG stem cells were delineated on the treatment planning CT, and the mean doses to the PG stem cells calculated. Results The total test score and mean doses to bilateral PGs were significantly correlated ( r = .34, P = .001), and the mean doses to bilateral PG stem cell niches were significantly correlated with the total test score ( r = .32, P = .002). Conclusions In this study, we found that the mean dose to PG stem cells can predict dry mouth as much as the mean dose to the PG.