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Regional disease control in sinonasal mucosal melanoma: Systematic review and meta‐analysis
Author(s) -
De Virgilio Armando,
Costantino Andrea,
Canzano Federica,
Accorona Remo,
Mercante Giuseppe,
Ferreli Fabio,
Malvezzi Luca,
Colombo Giovanni,
Pellini Raul,
Spriano Giuseppe
Publication year - 2021
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26537
Subject(s) - medicine , cochrane library , meta analysis , medline , subgroup analysis , surgery , political science , law
Purpose To systematically analyze the regional disease control after sinonasal mucosal melanoma (SNMM) primary treatment. Methods The study was performed according to the PRISMA guidelines searching on Scopus, PubMed/MEDLINE, Cochrane Library, and Google Scholar databases. Results A total of 15 studies with 936 patients (median age: 68.0 years, IQR 65‐71) were included. Overall, the cumulative regional recurrence rate (RRR) was 18.4% (n = 917, 99% CI: 14.0%‐23.4%), with a median follow‐up of 30.0 months (n = 765, IQR 22.0‐37.0). The RRR in clinical node negative patients was 17.0% (99% CI: 12.2%‐22.5%), with a median follow‐up of 22.0 months (n = 327, IQR 21.5‐31.5). Conclusions The RRR of SNMM after primary treatment is not to be neglected. Further prospective studies should be encouraged to clarify if elective treatment of the neck could be recommended at least in a subgroup of patients.