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Accuracy of f ine‐needle aspiration cytology in detecting cervical node metastasis after radiotherapy: Systematic review and meta‐analysis
Author(s) -
Costantino Andrea,
Mercante Giuseppe,
D'Ascoli Elisa,
Ferreli Fabio,
Di Tommaso Luca,
Franzese Ciro,
Giannitto Caterina,
Casale Manuele,
Spriano Giuseppe,
De Virgilio Armando
Publication year - 2021
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26536
Subject(s) - medicine , diagnostic odds ratio , meta analysis , context (archaeology) , cytology , odds ratio , neck dissection , radiation therapy , fine needle aspiration cytology , dissection (medical) , radiology , cancer , pathology , paleontology , biology
Purpose To define the accuracy of fine‐needle aspiration cytology (FNAC) in diagnosing persistent or recurrent neck metastases in previously irradiated patients. Methods The study was performed according to the PRISMA‐DTA guidelines. Results A total of 382 FNACs were used for calculation of diagnostic accuracy parameters. The overall pooled sensitivity and specificity in detecting malignant nodes were 69.1% (95% CI: 56.3%‐80.7%; I 2 = 79.5%) and 84.2% (95% CI: 71.8%‐93.5%; I 2 = 87.0%), respectively. Cumulative diagnostic odds ratio (DOR) was 16.54 (95% CI: 4.89‐38.99; I 2 = 65.8%), while cumulative positive and negative likelihood ratio (PLR and NLR) were 5.4 (95% CI: 2.3‐11.2) and 0.37 (95% CI: 0.22‐0.54), respectively. Conclusions FNAC alone could not guide the decision to perform a salvage neck dissection in previously irradiated patients, but its results should be assessed in relation to the specific clinical context.