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Population‐based analysis on the effect of nodal and distant metastases in sinonasal adenocarcinoma
Author(s) -
Chweya Cynthia M.,
Low Christopher M.,
Van Gompel Jamie J.,
Van Abel Kathryn M.,
Stokken Janalee K.,
Choby Garret
Publication year - 2021
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26457
Subject(s) - medicine , nodal , multivariate analysis , adenocarcinoma , epidemiology , overall survival , oncology , population , survival analysis , univariate analysis , relative survival , gastroenterology , surgery , cancer , cancer registry , environmental health
Background Minimal information has been reported on the effect of distant and nodal metastases at the time of diagnosis on survival in patients with sinonasal adenocarcinoma (SNAC). Methods The Surveillance, Epidemiology, and End Results database was utilized to compare overall survival (OS) and disease‐specific survival (DSS). Results Of the 325 patients with SNAC identified, 5‐year and 10‐year OS for all included patients was 64% and 58%, respectively. On multivariate analysis, the presence of distant metastases ( P < .0001), maxillary and frontal sinus primary tumors ( P = .0042, P = .0006), and increasing age ( P = .007) were risk factors for worsened DSS. The presence of regional spread to multiple cervical nodal basins (OS RR 3.26, P = .002; DSS RR 2.51, P = .013) and a single nodal basin (DSS RR 2.19, P = .046) was associated with worsened survival compared to no regional spread. Conclusion Survival in SNAC was significantly worsened with increasing age, tumor site of origin, and distant metastatic disease.