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Panendoscopy during follow‐up in laryngeal carcinoma patients after radiotherapy
Author(s) -
Stanisz Isabella,
Janik Stefan,
Grasl Matthäus Christoph,
Erovic Boban M.
Publication year - 2020
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26433
Subject(s) - medicine , radiation therapy , radiological weapon , confidence interval , odds ratio , retrospective cohort study , carcinoma , surgery , radiology
Background Early detection of a recurrent disease remains essential during follow‐up to improve outcome and reduce morbidity. The purpose of this study was to evaluate the adequacy of panendoscopy after radiotherapy for recurrent laryngeal carcinoma. Methods In this retrospective analysis, 623 patients were included. Clinical and radiological examinations were compared to pathohistological results of panendoscopy and clinical outcome. Results In the first 6 months after therapy, a negative histopathological result was significantly higher in patients after radiotherapy (n = 394) compared to patients after surgery (n = 195) alone (odds ratio [OR] 0.4424, 95% confidence interval [CI] 0.2081‐0.969, P = .05). After radiotherapy, a suspicious radiological result was not significantly linked to recurrence (OR 1.461, 95% CI 0.7126‐3.021, P = .37). Clinical investigation was the best predictive parameter for detecting recurrent disease after radiation therapy (OR 4.061, 95% CI 2.268‐7.113, P = <.0001). Conclusions Our results suggest that in the first 6 months after radiotherapy, emphasis should be placed on clinical evaluation during follow‐up.