Premium
Long‐term survival of head and neck squamous cell carcinoma after bone marrow transplant
Author(s) -
Douglas Catriona M.,
Jethwa Ashock R.,
Hasan Wael,
Liu Amy,
Gilbert Ralph,
Goldstein David,
De Almedia John,
Lipton Jeff,
Irish Jonathan C.
Publication year - 2020
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26402
Subject(s) - medicine , head and neck squamous cell carcinoma , head and neck cancer , oncology , cancer , stage (stratigraphy) , retrospective cohort study , bone marrow , population , bone marrow transplant , disease , surgery , bone marrow transplantation , paleontology , environmental health , biology
Purpose The risk of developing head and neck squamous cell carcinoma (HNSCC) in patients with graft versus host disease (GVHD) after bone marrow transplant (BMT) is well established but large series reporting outcomes are sparse. Methods Retrospective, single institution, study of patients with GVHD and HNSCC after BMT, between January 1, 1968, and June 30, 2016. Results In total, 25 patients were studied, of which 21 (84%) were male and 4 (16%) were female. Mean age for BMT was 41 (18‐65) years. All patients developed GVHD, most common site was oral cavity (19 patients, 76%). Mean age for diagnosis of HNSCC was 52 (28‐76) years. Mean time between BMT and diagnosis of HNSCC was 12 (2‐13) years. The 2‐year progression‐free survival (PFS) was 61.4%, 5‐year PFS was 56.7%. The 2‐year overall survival (OS) was 82.8%, 5‐year OS was 68.7%. Conclusion HNSCC can develop many years after BMT in patients without the classic risk factors for head and neck cancer. The majority were seen with oral cancer and with early‐stage disease likely due to active surveillance and early detection in this patient population.