Premium
The epidemiology, surgical management, and impact of margins in skull and mandibular osseous‐site tumors
Author(s) -
Torabi Sina J.,
Bourdillon Alexandra,
Salehi Parsa P.,
Kafle Samipya,
Mehra Saral,
Rahmati Rahmatullah,
Judson Benjamin L.
Publication year - 2020
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26389
Subject(s) - medicine , epidemiology , hazard ratio , multivariate analysis , head and neck , cohort , proportional hazards model , osteosarcoma , skull , surgery , oncology , pathology , confidence interval
Objective The aim of the study was to characterize the epidemiology and treatment outcomes of head and neck (HN) osseous‐site tumors. Methods Descriptive analyses and multivariate Cox regressions were performed to analyze the effect of surgery on overall survival (OS) utilizing the National Cancer Database (2004‐2016). Results Of 2449 tumors, surgery was utilized in 84.5% of cases. OS was worse in osteosarcoma (5‐year OS: 53.4% [SE: 2.5%]) compared with cartilage tumors (5‐year OS: 84.6% [SE: 1.8%]) (log‐rank P < .001). Treatment regimens that included surgery were associated with improved OS on multivariate analysis (hazard ratio [HR] 0.495 [95% CI: 0.366‐0.670]). Positive margins were found in 40.8% of cases, and associated with decreased OS in osteosarcomas (HR 1.304 [0.697‐2.438]). Conclusion Treatment that included surgery was associated with an increased OS within our cohort of HN osseous‐site tumors, although the rates of positive margins were >40%. These findings may be limited by inherent selection bias in the database.