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Outcome in patients with isolated regional recurrence after primary radiotherapy for head and neck cancer
Author(s) -
Lindegaard Anne Marie,
Buchwald Christian,
Rasmussen Jacob H.,
Specht Lena,
Vogelius Ivan R.,
Zamani Martin,
Woller Nina Claire,
Lelkaitis Giedrius,
Friborg Jeppe
Publication year - 2020
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26361
Subject(s) - medicine , salvage surgery , radiation therapy , head and neck squamous cell carcinoma , salvage therapy , multivariate analysis , oncology , head and neck cancer , univariate analysis , surgery , overall survival , cancer , stage (stratigraphy) , cohort , basal cell , chemotherapy , paleontology , biology
Background Isolated regional recurrences following head‐neck squamous‐cell carcinomas (HNSCC) are often accessible for curatively intended salvage treatment. Factors prognostic for outcome were investigated in a large cohort of HNSCC patients. Methods In total, 1811 patients receiving curatively intended radiotherapy from 2007 to 2017 were reviewed and isolated cervical nodal recurrences were identified. Factors associated with survival and second recurrence were investigated using univariate and multivariate analyses. Results Isolated regional recurrence was seen in 95/1811 (5.2%) patients. Eighty of 95 patients (84%) received salvage surgery. Two‐year survival after isolated regional recurrence was 40%. Overall survival (OS) and time to second recurrence were associated with resection status of the salvage surgery and presence of extranodal spread (ENS), while p16‐positive oropharyngeal squamous‐cell carcinoma (OPSCC) was associated with better OS. Conclusion Long‐term survival after regional recurrence in HNSCC is possible. p16‐positive OPSCC, complete salvage surgery, and lack of ENS are associated with better outcome.