Premium
Diabetes mellitus in major head and neck cancer surgery: Systematic review and meta‐analysis
Author(s) -
Caputo Mathew P.,
Shabani Sepehr,
Mhaskar Rahul,
McMullen Caitlin,
Padhya Tapan A.,
Mifsud Matthew J.
Publication year - 2020
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26349
Subject(s) - medicine , meta analysis , confidence interval , diabetes mellitus , head and neck cancer , relative risk , comorbidity , cancer , hazard ratio , population , surgery , medline , endocrinology , environmental health , political science , law
Background Diabetes mellitus (DM) is a risk factor for surgical complications and a common comorbidity in the setting of head and neck (H&N) cancer. Our objective was to determine if DM is associated with increased rates of H&N cancer surgery complications. Methods We conducted a search of Pubmed, Embase, and the national clinical trials database focusing on H&N cancer surgery or free flap reconstruction and diabetes. Two reviewers screened studies by title/abstract and then full text. We then collected data using a pre‐made template. Meta‐analysis was performed using Revman 5.3. Results Of the 272 results from Pubmed and 559 from Embase, we selected 16 studies for inclusion. Meta‐analysis revealed DM was associated with increased rates of flap failure (risk ratio [RR] = 1.83 95% confidence interval [CI], 1.18‐2.85; P = .007) and local complications (RR = 1.87 95% CI, 1.24‐2.80; P < .00001). Conclusion Although DM is associated with increased risk of flap failure and local H&N cancer surgery complications, further research is required to optimize care in this population.