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Prevalence of human papillomavirus in oral epithelial dysplasia: Systematic review and meta‐analysis
Author(s) -
de la Cour Cecilie Dovey,
Sperling Cecilie Dyg,
Belmonte Federica,
Syrjänen Stina,
Verdoodt Freija,
Kjaer Susanne Krüger
Publication year - 2020
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26330
Subject(s) - epithelial dysplasia , meta analysis , dysplasia , human papillomavirus , medicine , genotype , hpv infection , carcinogen , pathology , oncology , biology , cancer , cervical cancer , gene , genetics
The purpose of this systematic review and meta‐analysis was to estimate the overall and type‐specific prevalence of human papillomavirus (HPV) DNA in oral epithelial dysplasia and assess p16 INK4a overexpression in relation to HPV‐status. A systematic literature search identified 31 eligible studies (832 cases) evaluating the presence of HPV DNA in oral epithelial dysplasia cases by PCR. Of these, six studies evaluated p16 INK4a overexpression in relation to HPV‐status. The overall pooled prevalence of HPV DNA in oral epithelial dysplasia was 27.2% (95% CI: 17.6‐38.1). We observed substantial interstudy heterogeneity, which could not be explained by differences in continent, tissue type, or severity of epithelial dysplasia. HPV16 was the predominant genotype detected. Moreover, 62.2% of HPV positive and 17.8% of HPV negative oral epithelial dysplasia samples stained intensively positive for p16 INK4a . This meta‐analysis found that 27% of oral epithelial dysplasia harbor HPV DNA. Whether this represents a transient infection or has a carcinogenic role is unknown.