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Physical inactivity and head and neck cancer mortality
Author(s) -
Fried Jacob,
Etter John Lewis,
Stenzel Ashley E.,
Joseph Janine M.,
Cannioto Rikki,
Danziger Iris R.,
Moysich Kirsten B.
Publication year - 2020
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26283
Subject(s) - medicine , head and neck cancer , head and neck , hazard ratio , confidence interval , cancer , overweight , distant metastasis , pharynx , surgery , obesity , metastasis
Background This study was performed to examine the association between adulthood recreational physical inactivity (PIA) and mortality among patients with cancers of the head and neck. Methods Patients with head and neck cancer at Roswell Park between years 1990 to 1998 were included (N = 305). Multivariable Cox proportional hazard ratios (HR) with corresponding 95% confidence intervals (CI) were used to analyze the association between PIA and risk of dying. Results There was a 1.40‐fold increase in risk of dying among PIA patients, when compared to active patients with head and neck cancers (HR = 1.40, CI: 1.03‐1.91). This was observed greater in PIA women (HR = 2.40, CI: 1.28‐4.52), patients who were overweight/obese (HR = 1.76, CI: 1.09‐2.85), patients with pharynx as the primary site (HR = 1.85, CI: 1.01‐3.38), and patients with distant metastasis (HR = 5.19, CI: 1.37‐19.65). Conclusion Physically inactive patients with head and neck cancers are at significantly greater risk of dying when compared to patients who are active.