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Prognostic significance of human papillomavirus and Epstein‐Bar virus in nasopharyngeal carcinoma
Author(s) -
Verma Nipun,
Patel Suchit,
Osborn Virginia,
McBride Sean,
Riaz Nadeem,
Lee Anna,
Katabi Nora,
Sherman Eric,
Lee Nancy Y.,
Tsai Chiaojung J.
Publication year - 2020
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26245
Subject(s) - nasopharyngeal carcinoma , hazard ratio , medicine , proportional hazards model , confidence interval , oncology , stage (stratigraphy) , population , virus , carcinoma , survival analysis , epstein–barr virus , clinical significance , human papillomavirus , gastroenterology , immunology , biology , radiation therapy , paleontology , environmental health
Abstract Background The clinical significance of Epstein‐Barr virus (EBV) and human papillomavirus (HPV) infection in nasopharyngeal carcinoma (NPC) is unclear. Methods Three hundred and forty three patients with NPC diagnosed between 1998 and 2017 and treated at our institution were included. Chi‐square was used to identify characteristics associated with viral status. Kaplan‐Meier methods were used to estimate overall survival (OS) and Cox proportional regression was used to identify prognostic factors. Results Patients with HPV‐associated NPC were more likely to have a positive smoking history and to present at a higher T classification. At a median follow‐up time of 59.9 months (range: 0.1‐222.4 months), there were no differences in OS ( P = .198), time to local failure (LF, P = .403), or time to distant metastasis (DM, P = .849) between the viral subgroups. Older age (hazard ratio [HR]: 2.242, 95% confidence interval [CI] 1.374‐3.659, P = .001) and higher overall stage (HR: 2.047, 95% CI 1.235‐3.391, P = .005) were prognostic for worse OS. Conclusion In our population, viral status was not prognostic for OS, LF, or DM.