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Risk of second primary cancer in oral squamous cell carcinoma
Author(s) -
Mroueh Rayan,
Nevala Aapeli,
Haapaniemi Aaro,
Pitkäniemi Janne,
Salo Tuula,
Mäkitie Antti A.
Publication year - 2020
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26107
Subject(s) - medicine , incidence (geometry) , basal cell , cancer , relative risk , cancer registry , absolute risk reduction , primary care , primary cancer , population , relative survival , oncology , confidence interval , family medicine , environmental health , physics , optics
Background The incidence and survival of oral squamous cell carcinoma (OSCC) patients have increased in recent years. Understanding their long‐term survival aspects is essential for optimal treatment and follow‐up planning. Almost one in five cancers diagnosed occurs nowadays in individuals with a previous diagnosis of cancer. Methods Patients diagnosed with primary OSCC during 1953‐2015 were retrieved from the Finnish Cancer Registry. Both standardized incidence ratios (SIR) and excess absolute risk (EAR) per 1000 person‐years at risk (PYR) of second primary cancer (SPC) were calculated relative to the general population. Results Among 6602 first primary OSCC patients there were 640 (10%) SPCs. The SIR for SPCs was 1.85 (95% CI: 1.71‐1.99, P < .001) corresponding to an EAR of 8.78 (95% CI: 7.29‐10.26). Conclusions Health care professionals should be aware of the second primary cancer risk after management of primary OSCC and patients need to be counseled about this phenomenon.