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Soft tissue deposit in neck dissection specimen carries a poor prognosis in oral cancer: A matched pair analysis
Author(s) -
Malik Akshat,
Nair Sudhir,
Singh Arjun,
Lamba Komal,
Rane Swapnil,
Bal Munita,
Bhattacharjee Atanu,
Mehanna Hisham,
Chaturvedi Pankaj
Publication year - 2020
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26103
Subject(s) - medicine , neck dissection , soft tissue , hazard ratio , oncology , stage (stratigraphy) , cancer , surgery , confidence interval , paleontology , biology
Abstract Background Soft tissue deposit (STD) is the presence of tumor foci in the neck at sites other than lymphoid tissue. We evaluated the factors associated with STD and their impact on outcomes. Methods The records of 4812 treatment naïve oral cancers operated between December 2010 and September 2015 were screened for the presence of STD. A matched‐pair analysis was performed to obtain 450 patients without STD. Chi‐square was used to test association with clinicopathological factors and hazard ratio (HR) for overall survival (OS) and disease‐free survival (DFS) were calculated. Results STD was present in 0.6% and associated with gingiva‐buccal cancers, advanced stage, poor differentiation, presence of extranodal extension (ENE) and higher locoregional/distant metastasis. They had a significantly poorer OS (HR‐2.08; P ‐value .0073) and DFS (HR‐2.5; P‐value .0002) with and without ENE [HR‐1.96 and 3.7, respectively]. Conclusion Despite aggressive adjuvant therapy STD has a significant negative impact on outcomes.