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Analysis of patterns and risk factors regarding the onset of nodules in the contralateral thyroid lobe during follow‐up ultrasonography among patients after unilateral lobectomy for the treatment of papillary thyroid carcinoma
Author(s) -
Sun Chao,
Wang Qian,
Guo Qianqian,
Chang Qing,
Liang Xin,
Wang Dong,
Dai Hongbin,
Hu Zhiguang,
Xu Tianyu,
Feng Wenqi,
Li Zhengjiang,
Niu Lijuan
Publication year - 2020
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26056
Subject(s) - medicine , thyroid nodules , nodule (geology) , thyroid carcinoma , radiology , incidence (geometry) , malignancy , logistic regression , thyroid , lobe , risk factor , ultrasound , pathology , paleontology , physics , optics , biology
Background This study tries to find the patterns of new nodules in contralateral thyroid lobe among papillary thyroid carcinomas (PTCs) after lobectomy using ultrasonography. Methods Of note, 456 PTCs were enrolled. Clinicopathological features of primary tumors and sonographic patterns of new nodules in contralateral lobe were documented. Logistic regression analysis was performed to identify risk factors for new nodules. Results The overall incidence of new nodules was 41.9%. 96.3% of new nodules were no greater than 1 cm while only 10.5% of those were with high suspicion of malignancy. There was no difference in the incidence and sonographic patterns of new nodules between patients with an original tumor size <1 cm (n = 267) vs 1 to 4 cm (n = 189). Multivariate logistic regression analysis showed age (OR, 1.021; 95% CI, 1.001‐1.041; P = .036) played risk factor for new nodules while tumor size >1 cm did not. Conclusion New nodules in the contralateral lobe were common, but usually small and benign by ultrasound features. Older age was found to be a risk factor to predict new nodules. This study supports lobectomy for 1‐4 cm PTC in terms of incidence of new nodules on the remnant lobe.