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Pathologic response to neoadjuvant chemotherapy in HPV‐associated oropharynx cancer
Author(s) -
Sadeghi Nader,
Khalife Sarah,
Mascarella Marco A.,
Ramanakumar Agnihotram V.,
Richardson Keith,
Joshi Arjun S.,
Bouganim Nathaniel,
Taheri Reza,
Fuson Andrew,
Siegel Robert
Publication year - 2020
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26022
Subject(s) - medicine , docetaxel , chemotherapy , induction chemotherapy , oncology , neoadjuvant therapy , receiver operating characteristic , cancer , radiology , cisplatin , breast cancer
Background A paradigm shift has led to de‐escalation trials for the treatment of HPV‐positive oropharynx cancer (OPC). The objective of this study was to assess the ability of tumor volume reduction on imaging to predict pathological response to neoadjuvant chemotherapy in patients with HPV‐positive OPC. Methods A prospective observational study of 54 patients with HPV‐positive OPC enrolled in a clinical trial of neoadjuvant chemotherapy followed by surgery was performed. Patients underwent three cycles of induction chemotherapy (cisplatin/docetaxel); prechemotherapy and postchemotherapy imaging were obtained. Receiver operating characteristic curves and logistic regression analyses were used. Results The complete pathologic response (pCR) rate at primary and nodal sites were 72% and 57%, respectively. Tumor volume reduction of ≥90% following induction chemotherapy predicted pCR of the primary tumor. Conclusions Neoadjuvant chemotherapy followed by definitive transoral surgery is a new paradigm worthy of further investigation and MRI is a reliable modality to assess preoperative response.