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Minimally invasive surgery for laryngopharyngeal cancer: Multicenter feasibility study of a combination strategy involving transoral surgery and real‐time indocyanine green fluorescence‐navigated sentinel node navigation surgery
Author(s) -
Araki Koji,
Tomifuji Masayuki,
Shiotani Akihiro,
Hirano Shigeru,
Yokoyama Junkichi,
Tsukahara Kiyoaki,
Homma Akihiro,
Yoshimoto Seichi,
Hasegawa Yasuhisa
Publication year - 2020
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25993
Subject(s) - medicine , indocyanine green , sentinel node , hypopharyngeal cancer , surgery , metastasis , sentinel lymph node , survival rate , radiology , cancer , radiation therapy , breast cancer
Background Sentinel node navigation surgery using indocyanine green (ICG‐SNNS) can be performed in the operation room. The combination of minimally invasive transoral surgery (TOS) with ICG‐SNNS can provide functional preservation options for both primary lesions and lymph node (LN) metastasis. This multicenter feasibility study of this strategy was conducted in Japan. Methods Patients with clinical T1 or T2, N0 oropharyngeal, hypopharyngeal, or supraglottic cancer were enrolled. The identification rate of sentinel nodes, delayed cervical LN metastasis in 2 years, and survival rate were assessed. Results Twenty‐two patients (10 oropharynx, 8 hypopharynx, 4 supraglottic cancer) were enrolled. The identification rate was 100%. One case had delayed nodal metastasis. The accuracy was 95.5%, sensitivity was 75%, and specificity was 100%. The 5‐year disease‐specific survival was 100%, overall survival was 72.3%, and disease‐free survival was 60.5%. Conclusions The combination of TOS with ICG‐SNNS is feasible as a minimally invasive strategy and has favorable oncological outcomes.