Premium
Patterns of local recurrence after curative resection and reconstruction for oropharyngeal and oral cancers: Implications for postoperative radiotherapy target volumes
Author(s) -
Cho Yeona,
Yoon Hong In,
Lee Ik Jae,
Kim Jun Won,
Lee Chang Geol,
Choi Eun Chang,
Kim SeHeon,
Keum Ki Chang
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25928
Subject(s) - medicine , perineural invasion , surgery , anastomosis , radiation therapy , lymph node metastasis , distant metastasis , free flap , lymph node , metastasis , cancer
Background We aimed to determine the patterns of local recurrence after curative resection and reconstruction for oropharyngeal and oral cancers. Methods One hundred‐fourteen patients with oropharyngeal and oral cancers underwent resection and reconstruction. The local recurrences were classified as “intra‐flap” (the recurrent tumor was located in the flap tissue), “marginal” (≤5 mm from the flap anastomosis), and “outside” (in the original tissue and >5 mm from the anastomosis) recurrences. Results Twenty‐seven patients (23.7%) experienced local recurrence, while 32 (28.1%) experienced regional, and nine (7.9%) recurred distantly. Among those who showed local recurrence, one developed “outside” recurrence and the remaining 26 developed “marginal” recurrences. Age >60 years and lymph node metastasis were associated with poor disease‐free survival and overall survival (OS), while the perineural invasion was related to poor locoregional failure‐free survival and OS. Conclusion Most recurrences developed at the anastomosis marginal site, while none developed in the flap tissue.