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The impact of treatment package time on locoregional control for HPV+ oropharyngeal squamous cell carcinoma treated with surgery and postoperative (chemo)radiation
Author(s) -
Chao HannHsiang,
Schonewolf Caitlin A.,
Tan Erik X.,
SwisherMcClure Samuel,
Ghiam Alireza F.,
Weinstein Gregory S.,
O'Malley Bert W.,
Chalian Ara A.,
Rassekh Christopher H.,
Newman Jason G.,
Cohen Roger B.,
Bauml Joshua M.,
Aggarwal Charu,
Lin Alexander,
Lukens John N.
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25914
Subject(s) - medicine , surgery , radiation therapy , multivariate analysis , cohort , oncology
Background For patients with head and neck squamous cell carcinoma (SCC) undergoing surgery followed by postoperative radiotherapy (PORT), time from surgery to completion of adjuvant therapy, “package time” impacts locoregional control (LRC). However, the significance of package time in HPV+ oropharyngeal SCC (OPSCC) is unknown. Methods We examined patients undergoing TORS resection with PORT for HPV+ OPSCC from January 2010 to December 2015 with ≥18 months follow‐up (n = 267). A cutoff of 15 weeks was used to delineate patients into short and long package time groups. LRC loss was defined as any recurrence after surgery. Results Prolonged package time >15 weeks was associated with inferior LRC in this HPV+ OPSCC cohort, driven primarily by interval from surgery to PORT initiation. Multivariate analysis showed that package time and T classification are both independently associated with LRC. Conclusions Among HPV+ OPSCC, prolongation of package time appears to compromise LRC, but not survival.