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A nomogram to estimate the risk of developing distant metastases in parotid cancer
Author(s) -
Locatello Luca Giovanni,
Cannavicci Angelo,
Bruno Chiara,
Maggiore Giandomenico,
Napoleone Vincenzo,
Gallo Oreste
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25843
Subject(s) - nomogram , medicine , adenoid cystic carcinoma , perineural invasion , cancer , oncology , radiology , carcinoma
Background Parotid cancer (PC) is a heterogeneous group of malignant tumors whose management mainly focuses on locoregional control. However, distant metastases (DM) can represent the most common cause of treatment failure. We have defined the predictors and developed a model that can predict a single patient's risk to develop DM. Methods We have analyzed our institutional database of 259 patients with PC and use it to develop a nomogram. C‐index and calibration curves were used to assess performance of our model. Results DM appeared in 18.9% of patients. Age, cT, pN, perineural invasion, and adenoid cystic carcinoma were significantly associated with distant failure. Conclusions We here present the first model to identify patients with PC at high risk of DM. Such tool can be of great value in managing these rare cancers in terms of a more precise prognosis and follow‐up while waiting for better systemic therapies to come in the future.