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Prediction of survival with combining quantitative 18 F‐FDG PET/CT and DW‐MRI parameters in sinonasal malignancies
Author(s) -
Ozturk Kerem,
Gencturk Mehmet,
CaicedoGranados Emiro,
Li Faqian,
Cayci Zuzan
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25799
Subject(s) - medicine , perineural invasion , positron emission tomography , nuclear medicine , proportional hazards model , survival analysis , head and neck cancer , progression free survival , standardized uptake value , overall survival , radiology , cancer , oncology , radiation therapy
Background We aimed to establish the prognostic value of 18 F‐fluoro‐deoxy‐glucose positron emission/CT ( 18 F‐FDG PET/CT) and diffusion‐weighted (DW) MRI in determining overall survival (OS), progression‐free survival (PFS), and distant metastasis‐free survival (DMFS) of sinonasal malignancies. Methods Sixty‐eight patients with sinonasal cancer who underwent both pretreatment 18 F‐FDG PET/CT scan and head‐neck MRI from January 2009 through August 2017 were retrospectively reviewed. Kaplan‐Meier survival analysis of 18 F‐FDG PET/CT and DW‐MRI parameters were performed for OS, PFS, and DMFS. Results Cox regression analysis determined that all the quantitative 18 F‐FDG PET/CT and DW‐MRI parameters were independently correlated with PFS, DMFS, and OS ( P < .05). After controlling for imaging variables, perineural invasion ( P = .02) and ill‐defined margin ( P = .02) were found to be significantly correlated with shorter OS; while the perineural invasion was significantly correlated with shorter PFS ( P = .02). Conclusions The pretreatment DW‐MRI and 18 F‐FDG PET/CT parameters could be substantial surrogate markers for sinonasal malignancies.