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Survival of oral tongue squamous cell carcinoma in young adults
Author(s) -
Oliver Jamie R.,
Wu S. Peter,
Chang Clifford M.,
Roden Dylan F.,
Wang Binhuan,
Hu Kenneth S.,
Schreiber David,
Givi Babak
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25772
Subject(s) - medicine , tongue , cohort , proportional hazards model , basal cell , propensity score matching , cancer , stage (stratigraphy) , overall survival , t stage , multivariate analysis , oncology , gastroenterology , pathology , biology , paleontology
Background Small cohort studies have suggested oral tongue squamous cell carcinoma (OTSCC) could be associated with worse prognosis in individuals younger than 40. Methods We compared the survival of all OTSCC cases in the National Cancer Database under 40 years old with those older than 40, excluding patients over 70. Cox regression and propensity score matched (PSM) survival analyses were performed. Results A total of 22 930 OTSCC patients were identified. The under 40 group consisted of 2566 (9.9%) cases; 20664 were 40 to 70 (90.1%). Most were male (13 713, 59.8%), stage I‐II (12 754, 72.4%), and treated by surgery alone (13 973, 63.2%). Survival in patients under 40 was higher (79.6% vs 69.5%, P < .001). In PSM analysis (n = 2928) controlling for all 10 significant factors in multivariate regression, patients under 40 had a 9% higher 5‐year survival (77.1% vs 68.2%, P < .001). Conclusion Contrary to the prior reports, younger patients with OTSCC did not have worse survival in the National Cancer Database.