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Clinicopathological predictors of occult lateral neck lymph node metastasis in papillary thyroid cancer: A meta‐analysis
Author(s) -
Zhan Shaohua,
Luo Dan,
Ge Wei,
Zhang Bin,
Wang Tianxiao
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25762
Subject(s) - medicine , occult , odds ratio , papillary thyroid cancer , oncology , metastasis , lymph node , lymph node metastasis , meta analysis , confidence interval , radiology , cancer , thyroid cancer , pathology , alternative medicine
Background This meta‐analysis aimed to identify the clinicopathological factors that could predict the risk of occult lateral neck lymph node metastasis (OLLNM) in N0/N1a papillary thyroid cancer (PTC). Methods A literature search of PubMed, Web of Science, OvidSP, and Chinese National Knowledge Infrastructure databases was performed using relevant keywords. Specific odds ratios and confidence intervals were calculated. Results The final analysis included 15 studies with a total of 5342 patients. OLLNM was found to be significantly associated with some clinicopathological features, including age <45 years, male sex, extrathyroidal extension, tumor location in the upper pole, tumor size >10 mm, positive central lymph node metastasis, number of central lymph node metastasis ≥3, and vascular invasion. Conclusions Fine‐needle aspiration (FNA) cytology or FNA‐Tg test might be an appropriate and reasonable intervention in the patients with N0/N1a PTC with an increased risk of OLLNM.