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The role of the T‐N tract in advanced stage tongue cancer
Author(s) -
Tagliabue Marta,
Gandini Sara,
Maffini Fausto,
Navach Valeria,
Bruschini Roberto,
Giugliano Gioacchino,
Lombardi Francesca,
Chiocca Susanna,
Rebecchi Elisabetta,
Sica Eleonora,
Tommasino Massimo,
Calabrese Luca,
Ansarin Mohssen
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25761
Subject(s) - tongue , medicine , hazard ratio , proportional hazards model , stage (stratigraphy) , t stage , oncology , gastroenterology , cancer , cumulative incidence , multivariate analysis , tongue neoplasm , pathology , confidence interval , cohort , biology , paleontology
Background We investigated the role of the soft tissue tract between the primary tumor and the neck lymph nodes, the “T‐N tract,” in patients with tongue squamous cell carcinoma at an advanced stage. Methods We performed a compartmental tongue surgery in 233 patients. Cumulative incidence of relapses and overall survival curves were compared by T‐N tract involvement. Multivariate Cox proportional hazards models were used to assess the independent role of T‐N tract. Results At 4 years of follow‐up, patients with disease in the T‐N tract experienced a significantly more distant recurrence (40%) than did patients without T‐N tract involvement (22%; P = .02). Multivariate Cox models indicate a significant almost triple risk of distant metastases (hazard ratio [HR], 2.70; 95% CI, 1.01‐7.19; P = .05) and double risk of death (HR, 2.09; 95%CI, 1.13‐3.85; P = .02) in patients with “T‐N tract involvement.” Conclusions Our data show that the T‐N tract plays an important role in prognosis and survival in patients with tongue cancer.