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American Joint Committee on Cancer eighth edition human papilloma virus positive oropharyngeal cancer staging system: Discordance between clinical and pathological staging systems
Author(s) -
Hall Scott R.,
Neel Gregory S.,
Chang Brent A.,
Howard Brittany E.,
Nagel Thomas H.,
Lott David G.,
Hayden Richard E.,
Zhang Nan,
Hinni Michael L.
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25749
Subject(s) - medicine , ajcc staging system , cancer , pathological , stage (stratigraphy) , cancer staging , retrospective cohort study , human papillomavirus , cohort , pathological staging , oncology , staging system , paleontology , biology
Background The American Joint Committee on Cancer (AJCC) eighth edition introduces a staging system specific for human papilloma virus positive oropharyngeal cancer with separate clinical (AJCC 8c) and pathological (AJCC 8p) criteria. Methods In this retrospective cohort study, preoperative imaging and pathology reports were used to stage patients based on the AJCC 8c and AJCC 8p criteria, respectively. The primary endpoint was agreement between AJCC 8c and AJCC 8p. Results A total of 213 patients met inclusion criteria. Kappa statistics showed poor agreement ( κ = 0.3275) between AJCC 8c and AJCC 8p. In total, 30.3% of patient's preoperative AJCC 8c stage changed based on the postoperative pathologic staging (AJCC 8p) with 73.4% of those being upstaged. Conclusion These data suggest that disagreement exists between AJCC 8c and AJCC 8p, in part due to the separate clinical and pathological staging criteria. This discrepancy should be considered as the new system is implemented.