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CASP9 c.‐1339A>G and CASP3 c.‐1191A>G polymorphisms alter susceptibility and clinical aspects of head and neck squamous cell carcinoma
Author(s) -
Costa Ericka Francislaine Dias,
LopesAguiar Leisa,
Nogueira Guilherme Silva,
Lima Tathiane Regine Penna,
RinckJunior José Augusto,
Lourenço Gustavo Jacob,
Lima Carmen Silvia Passos
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25746
Subject(s) - genotype , head and neck squamous cell carcinoma , genotyping , single nucleotide polymorphism , head and neck cancer , basal cell , biology , gene , polymerase chain reaction , cancer research , cancer , microbiology and biotechnology , medicine , pathology , genetics
Background Single nucleotide polymorphisms (SNPs) in genes that act in intrinsic apoptosis pathway may modulate cancer susceptibility. This study investigated the roles of CASP9 c.‐1339A>G (rs4645978) and CASP3 c.‐1191A>G (rs12108497) SNPs on risk and behavior of head and neck (HN) squamous cell carcinoma (SCC). Methods DNA of 350 patients with HNSCC and 350 controls was analyzed by polymerase chain reaction method for genotyping. Results CASP3 c.‐1191AG or GG genotype was more common in patients with HNSCC and oral cavity or oropharynx SCC than in controls; carriers of this genotype were under 2.15 and 2.81‐fold increased risks of the respective tumors. CASP9 c.‐1339AG or GG plus CASP3 c.‐1191AG or GG genotypes were associated with oral cavity or oropharynx SCC early onset. Conclusion These findings present, for the first time, preliminary evidence that inherited abnormalities related to CASP9 c.‐1339A>G and CASP3 c.‐1191A>G SNPs are determinants of HNSCC risk and clinical aspects.