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Dynamic changes in chemosensitivity immune predictors in patients with hypopharyngeal cancer treated with induction chemotherapy
Author(s) -
Sun Wei,
Chen Lin,
Huang JinQiang,
Li Jian,
Zhu XiaoLin,
Wen YiHui,
Wen WeiPing
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25699
Subject(s) - cd8 , immune system , hypopharyngeal cancer , chemotherapy , induction chemotherapy , medicine , cell , oncology , cancer research , immunology , cancer , biology , genetics
Abstract Background There are currently no data predicting chemosensitivity of induction chemotherapy (ICT) for hypopharyngeal squamous cell carcinomas (SCC). Methods Associations between immune cells and overall response (OR) to ICT and changes in immune cells during ICT were observed in 40 patients with hypopharyngeal SCC undergoing ICT. Results CD4 + and CD8 + T‐cell and regulatory T‐cell (Treg) frequencies reached diagnostic accuracy for OR to ICT. OR rate was significantly higher in CD4 + ‐high T cell, CD8 + ‐high T cell, and low Treg groups. A transient reduction in Tregs and increases in Tregs in the non‐OR and OR groups were observed during the course of ICT. Conversely, increases in CD8 + T cells and reductions in CD8 + T cells in the non‐OR and OR groups were observed. Conclusion High CD4 + T‐cell, high CD8 + T‐cell, and low Treg frequencies can be predictors for high efficacy of ICT in patients with hypopharyngeal SCC.