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Dietary behaviors and survival in people with head and neck cancer: Results from Head and Neck 5000
Author(s) -
Lang Samantha,
Schimansky Sarah,
Bey Rhona,
Penfold Christopher,
Davies Amy,
Waylen Andrea,
Thomas Steven,
Pring Miranda,
Pawlita Michael,
Waterboer Tim,
Ness Andrew R.
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25660
Subject(s) - medicine , confounding , hazard ratio , head and neck cancer , proportional hazards model , alcohol consumption , survival analysis , alcohol intake , cancer , alcohol , confidence interval , biology , biochemistry
Background The association between diet and head and neck cancer (HNC) survival is unclear. Methods Cox proportional hazard models measured the association between fruit, vegetable, and deep‐fried food intake and HNC overall survival adjusting for clinical, social and lifestyle variables including smoking, alcohol, and HPV status. Results Fruit and vegetable intake and improved survival were associated in minimally adjusted analyses. Following adjustment for smoking and alcohol consumption (fully adjusted analyses), the association with survival disappeared for fruit (HR 0.91, 95% CI 0.67, 1.23; P for trend = .55) and attenuated for vegetables (HR 0.79, 95% CI 0.61, 1.03; P for trend = .04). We observed no association between survival and deep‐fried food intake in minimally adjusted or fully adjusted analyses (HR 0.88 95% CI 0.72, 1.07; P for trend = .13). Conclusions Vegetable intake and HNC survival are modestly associated. There is some confounding by tobacco and alcohol consumption.